What question did this study set out to answer?

The aim is to establish a method for synthesizing cinnoline-4-carbaldehyde derivatives through metal-catalyzed reactions.

May 8, 2026The Journal of Organic Chemistry0 citations

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Direct Access to Cinnoline-4-carbaldehydes: Iridium(III)-Catalyzed C–H 4 + 2 Annulation Using 2-Chloromalonaldehyde as a C 2 Synthon

CZChao ZhangNational Medical Products Administration GQGuanyu QiaoNational Medical Products Administration LDLin DongNational Medical Products Administration

Key Points

The aim is to establish a method for synthesizing cinnoline-4-carbaldehyde derivatives through metal-catalyzed reactions.
Utilized iridium(III) as a catalyst for C–H annulation.
Employed 2-chloromalonaldehyde as a C2 synthon.
Executed a dephthaloylation step for functionalization.
Successfully synthesized cinnoline-4-carbaldehyde derivatives with high efficiency.
Facilitated direct installation of aldehyde groups for further functionalization.

Abstract

synthon in metal-catalyzed cyclization reactions; (ii) the direct and efficient installation of an aldehyde group, a versatile synthetic handle and reactive motif enabling subsequent functionalization; and (iii) a subsequent dephthaloylation step that affords synthetically valuable cinnoline-4-carbaldehyde derivatives.

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Direct Access to Cinnoline-4-carbaldehydes: Iridium(III)-Catalyzed C–H 4 + 2 Annulation Using 2-Chloromalonaldehyde as a C 2 Synthon

Key Points

Abstract

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