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Occupational physical work exposure is associated with an increased risk of wild-type transthyretin cardiomyopathy (ATTRwt-CM). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 27, 2026Open Access

Association Between Occupational Physical Work Exposure and Wild-Type Transthyretin Cardiomyopathy

Key Points

This study aims to investigate the link between occupational physical work exposure and wild-type transthyretin cardiomyopathy.
Analyzed the association between occupational upper-body mechanical stress and ATTRwt-CM
Assessed comorbidities related to cardiovascular health in patients with ATTRwt-CM
Used observational study design to gather and correlate data
Found higher occupational mechanical stress in patients with wild-type transthyretin cardiomyopathy
Patients had increased orthopedic and cardiovascular comorbidities
Noted higher cardiovascular mortality among these patients

Abstract

ATTRwt-CM was associated with greater occupational upper-body mechanical stress. While a causal relationship cannot be established due to study design, the results are hypothesis generating for the development of ATTRwt-CM. Additionally, ATTRwt-CM patients had a greater burden of orthopedic and cardiovascular comorbidities including increased cardiovascular mortality.

Association Between Occupational Physical Work Exposure and Wild-Type Transthyretin Cardiomyopathy

Key Points

Abstract

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