Observational study associates occupational stress with transthyretin cardiomyopathy in adults, suggesting potential health risks.
ATTRwt-CM was associated with greater occupational upper-body mechanical stress. While a causal relationship cannot be established due to study design, the results are hypothesis generating for the development of ATTRwt-CM. Additionally, ATTRwt-CM patients had a greater burden of orthopedic and cardiovascular comorbidities including increased cardiovascular mortality.
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Ladefoged et al. (2026) studied this question.
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