What is the clinical evidence from this study?

Study design: Observational. Population: Wild-Type Transthyretin Amyloid Cardiomyopathy (ATTRwt-CM). Intervention: Atrial fibrillation. Primary outcome: Prevalence of atrial fibrillation and incidence of systemic thromboembolism.

What question did this study set out to answer?

Determine the prevalence of atrial fibrillation and evaluate the incidence and clinical predictors of systemic thromboembolism in patients with wild-type transthyretin amyloid cardiomyopathy.

September 2, 2026CirculationOpen Access

Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy

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Key result

Observational cohort evaluates atrial fibrillation prevalence and thromboembolic risk in wild-type ATTR cardiomyopathy.

Population

Patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM)

Design

Cohort

Authors

SBSyed BukhariCardiac Imaging ABAmr F. BarakatElectrophysiology YEYvonne S. EiseleUniversity of Pittsburgh

Discussion

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Implication

Observational study reports atrial fibrillation frequency and thromboembolic risk in wild-type transthyretin amyloid cardiomyopathy, indicating key clinical risks of cardiac amyloid deposition.

Key Points

Determine the prevalence of atrial fibrillation and evaluate the incidence and clinical predictors of systemic thromboembolism in patients with wild-type transthyretin amyloid cardiomyopathy.
Evaluated a clinical cohort of patients diagnosed with wild-type transthyretin amyloid cardiomyopathy.
Assessed cardiac records to identify atrial fibrillation cases and tracked systemic thromboembolic complications and associated risk factors.
Characterized the burden of atrial fibrillation secondary to age-related amyloid fibril deposition and myocardial infiltration.
Identified risk patterns for systemic thromboembolic events among patients with concurrent cardiac amyloidosis and atrial arrhythmias.

Study Design

Type

Observational

Structured PICO

Population

Patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM)

Outcome

Prevalence of atrial fibrillation (AF) and the incidence and predictors of systemic thromboembolismhard clinical

Cite This Study

Bukhari et al. (2021) conducted an observational in Wild-Type Transthyretin Amyloid Cardiomyopathy (ATTRwt-CM). Atrial fibrillation was evaluated on Prevalence of atrial fibrillation and incidence of systemic thromboembolism. The abstract describes the objective to determine the prevalence of atrial fibrillation and thromboembolic risk in ATTRwt-CM, but provides no quantitative results.

synapsesocial.com/papers/6a97e9fa0e613c950205a1fd https://doi.org/10.1161/circulationaha.120.052136

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Implication

Observational study reports atrial fibrillation frequency and thromboembolic risk in wild-type transthyretin amyloid cardiomyopathy, indicating key clinical risks of cardiac amyloid deposition.

Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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