What does this research mean for the field?

Engaging a specific target reduces nicotine craving in individuals with psychotic disorders. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to explore the relationship between nicotine use, craving, and psychosis, and to identify a novel intervention target.

March 2, 2026Open Access

Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders

Key Points

The aim is to explore the relationship between nicotine use, craving, and psychosis, and to identify a novel intervention target.
Utilized network-targeted transcranial magnetic stimulation (TMS)
Examined its effects on nicotine craving
Analyzed default mode network connectivity in participants with psychotic disorders
Engaging the network target significantly reduced nicotine craving
Altered default mode network connectivity was observed
Supports the idea of using TMS as an intervention for nicotine use in psychosis

Abstract

We identified a potential mechanism of nicotine use in psychosis and demonstrated that engaging this target reduces craving, suggesting a novel target for nicotine interventions in psychosis.

Bookmark

View Full Paper