Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders

Q: What does this research mean for the field?

Engaging a specific target reduces nicotine craving in individuals with psychotic disorders. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Heather Burrell Ward; Sophia H. Blyth; V M SIMON; Baxter P. Rogers; Gulcan Yildiz; Jillian Connolly; Brett A. Clementz; Elliot Gershon; Vijay A. Mittal; Jennifer E. McDowell; Meda Shashwath; Godfrey Pearlson; Carol A. Tamminga; Mark A. Halko; Roscoe O. Brady

doi:10.1016/j.brs.2026.103064

February 26, 2026Brain stimulationOpen Access

Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders

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Key Points

The aim is to explore the relationship between nicotine use, craving, and psychosis, and to identify a novel intervention target.
Utilized network-targeted transcranial magnetic stimulation (TMS)
Examined its effects on nicotine craving
Analyzed default mode network connectivity in participants with psychotic disorders
Engaging the network target significantly reduced nicotine craving
Altered default mode network connectivity was observed
Supports the idea of using TMS as an intervention for nicotine use in psychosis

Implication

This research demonstrates how targeted TMS reduces nicotine craving in psychosis, suggesting new intervention strategies.

Abstract

We identified a potential mechanism of nicotine use in psychosis and demonstrated that engaging this target reduces craving, suggesting a novel target for nicotine interventions in psychosis.

Discussion

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Cite This Study

Ward et al. (2026) studied this question.

synapsesocial.com/papers/69a528b3f1e85e5c73bf02ec https://doi.org/10.1016/j.brs.2026.103064

View Full Paper

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Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders

Key Points

Implication

Abstract

Discussion

Cite This Study

Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders

Key Points

Implication

Abstract

Discussion

Cite This Study

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