This study provides the first evidence of glymphatic functional impairment in patients with CD. Our findings suggest that aberrantly elevated midnight cortisol levels serve as a primary driver of this glymphatic functional impairment. Furthermore, this impaired glymphatic function fully mediates the impact of 00: 00 cortisol levels on microstructural injury to the SLF IIIR.
Sun et al. (Sun,) studied this question.