Demonstrates glymphatic dysfunction affecting white matter injury in Cushing's disease, indicating a crucial link.
This study provides the first evidence of glymphatic functional impairment in patients with CD. Our findings suggest that aberrantly elevated midnight cortisol levels serve as a primary driver of this glymphatic functional impairment. Furthermore, this impaired glymphatic function fully mediates the impact of 00:00 cortisol levels on microstructural injury to the SLF III_R.
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