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February 2, 2026Stroke

Abstract TP073: Glymphatic Dysfunction Is Impaired In Sickle Cell Disease And Associated With Microstructural Damage And Slower Processing Speed

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Authors

YWYan Mei WangSFSlim FellahSASerguei V. Astafiev

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Overview

Demonstrates impaired glymphatic clearance in sickle cell disease, suggesting links to brain injury and cognitive deficits.

Key Points

  • The research aims to explore the association between glymphatic clearance, cognitive function, and brain injury in sickle cell disease.
  • Compared ALPS index between adults with sickle cell disease and controls using diffusion tensor MRI.
  • Quantified brain injury using white matter microstructural measures and assessed inflammation via blood metrics.
  • Evaluated cognitive function with the Pattern Comparison Processing Speed Test.
  • Used Pearson correlations to examine relationships between ALPS index and various other variables.
  • ALPS index was significantly lower in individuals with sickle cell disease compared to controls.
  • A negative correlation was found between ALPS index and processing speed in the sickle cell cohort.
  • No associations were found between glymphatic clearance and blood-brain barrier permeability in the study.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6980fc17c1c9540dea80deefhttps://doi.org/10.1161/str.57.suppl_1.tp073
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