Phenylboronic acid-modified magnetic beads combined with DNA-anchored near-infrared AIEgen-based ultrasensitive signal tags for Argonaute-based biosensing

Key Points

• The combination of phenylboronic acid-modified magnetic beads with DNA tags significantly enhances biosensing sensitivity.
• A detection limit as low as 0.1 picomolar was achieved, showcasing the method's potential in biosensor applications.
• Assessment using innovative near-infrared AIEgen-based signal tags shows improved performance over traditional methods.
• Implications suggest this approach could revolutionize biosensing technology, requiring further validation in clinical settings.