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January 28, 2026Biosensors and Bioelectronics

Phenylboronic acid-modified magnetic beads combined with DNA-anchored near-infrared AIEgen-based ultrasensitive signal tags for Argonaute-based biosensing

Xuewen Peng Suya Yang Zhengzhang Huang Niu Feng Hetong Zhang Yiqi Li Yating Han Caiyang Zhang Jimei Ma Yiping Chen

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Key Points

The combination of phenylboronic acid-modified magnetic beads with DNA tags significantly enhances biosensing sensitivity.
A detection limit as low as 0.1 picomolar was achieved, showcasing the method's potential in biosensor applications.
Assessment using innovative near-infrared AIEgen-based signal tags shows improved performance over traditional methods.
Implications suggest this approach could revolutionize biosensing technology, requiring further validation in clinical settings.

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Implication

Analysis reveals enhanced biosensing sensitivity using novel DNA-anchored signal tags for Argonaute detection.

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Cite This Study

Peng et al. (2026) studied this question.

synapsesocial.com/papers/69a75c7ec6e9836116a256d2 https://doi.org/10.1016/j.bios.2026.118450

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