Bifidobacterium longum CBi0703 lysate modulates oxidative stress induced apoptosis and cartilage related gene expression in SW1353 chondrocytes: in vitro insights into the gut joint axis in Osteoarthritis

Key Points

• Modulating oxidative stress reduces apoptosis in chondrocytes, highlighting a protective role.
• Bifidobacterium longum CBi0703 lysate modifies cartilage-related gene expression, enhancing cellular health.
• Assessment using in vitro chondrocytes reveals significant impacts on oxidative stress responses.
• Findings suggest potential therapeutic avenues for osteoarthritis, emphasizing the gut joint axis.