Bifidobacterium longum CBi0703 lysate modulates oxidative stress induced apoptosis and cartilage related gene expression in SW1353 chondrocytes: in vitro insights into the gut joint axis in Osteoarthritis

Anna Mas-Capdevila; Lydia Carrera-Marcolin; Jordina Balaguer-Trias; Cristina Domenech-Coca; Yaiza Tobajas; Jordi Cuñé-Castellana; Jordi Romero‐Giménez; Maria Tintoré; Carlos de Lecea; Roger Mariné-Casadó; Xavier Escoté

doi:10.1038/s41598-026-37552-5

January 29, 2026Scientific ReportsOpen Access

Bifidobacterium longum CBi0703 lysate modulates oxidative stress induced apoptosis and cartilage related gene expression in SW1353 chondrocytes: in vitro insights into the gut joint axis in Osteoarthritis

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Key Points

Modulating oxidative stress reduces apoptosis in chondrocytes, highlighting a protective role.
Bifidobacterium longum CBi0703 lysate modifies cartilage-related gene expression, enhancing cellular health.
Assessment using in vitro chondrocytes reveals significant impacts on oxidative stress responses.
Findings suggest potential therapeutic avenues for osteoarthritis, emphasizing the gut joint axis.

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Implication

In vitro insights reveal that Bifidobacterium longum CBi0703 lysate modulates oxidative stress and apoptosis in chondrocytes, suggesting a gut-joint connection in osteoarthritis.

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Mas-Capdevila et al. (2026) studied this question.

synapsesocial.com/papers/69a75dd5c6e9836116a2818c https://doi.org/10.1038/s41598-026-37552-5

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Bifidobacterium longum CBi0703 lysate modulates oxidative stress induced apoptosis and cartilage related gene expression in SW1353 chondrocytes: in vitro insights into the gut joint axis in Osteoarthritis

Key Points

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Implication

Discussion

Cite This Study

Bifidobacterium longum CBi0703 lysate modulates oxidative stress induced apoptosis and cartilage related gene expression in SW1353 chondrocytes: in vitro insights into the gut joint axis in Osteoarthritis

Key Points

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Implication

Discussion

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