Reproductive and obstetric outcomes following frozen embryo transfer: letrozole combined with human menopausal gonadotropin versus hormone replacement cycle

Key Points

• Comparable low birth rates were observed between both OI and HRT protocols, indicating similar effectiveness.
• The OI protocol was linked to a lower incidence of cesarean sections, with a noteworthy reduction in gestational diabetes mellitus risks.
• Exploratory subgroup analyses suggest some patient groups may experience different responses to the interventions tested.
• Prospective validation of these findings is essential to confirm the initial outcomes observed.