March 3, 2026Frontiers in Endocrinology0 citationsOpen Access

Reproductive and obstetric outcomes following frozen embryo transfer: letrozole combined with human menopausal gonadotropin versus hormone replacement cycle

HGHuijuan GuanLianyungang Maternal and Children’s Hospital HTHuai-Yun TangLianyungang Maternal and Children’s Hospital HLHui LiLianyungang Maternal and Children’s Hospital

Key Points

Comparable low birth rates were observed between both OI and HRT protocols, indicating similar effectiveness.
The OI protocol was linked to a lower incidence of cesarean sections, with a noteworthy reduction in gestational diabetes mellitus risks.
Exploratory subgroup analyses suggest some patient groups may experience different responses to the interventions tested.
Prospective validation of these findings is essential to confirm the initial outcomes observed.

Abstract

Adjusted analysis revealed comparable LBR between the OI and HRT protocols. The OI protocol was associated with a lower risk of cesarean section and GDM in the overall population, with exploratory subgroup analyses suggesting potential differential effects in specific patient groups. These findings warrant prospective validation.

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