March 3, 2026Open Access

Novel Cyclopentapyrrole Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia

Key Points

Orexin receptor agonists show promise in alleviating symptoms of sleep disorders like narcolepsy and hypersomnia.
New cyclopentapyrrole compounds are developed to target these receptor mechanisms effectively.
Pharmaceutical compositions of these compounds are designed for use in treating sleep disorders.
The findings may support further development of targeted therapies for sleep-related issues.

Abstract

Provided herein are novel cyclopentapyrrole compounds as orexin receptor agonists, pharmaceutical compositions, use of such compounds in treating sleep disorders, namely, narcolepsy and hypersomnia, and processes for preparing such compounds.

Novel Cyclopentapyrrole Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia

Key Points

Abstract

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