Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT | Synapse
March 3, 2026
Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT
Key Points
Severe acute GVHD and non-relapse mortality rates are significantly higher in overweight and obese patients.
A notable 30% increase in non-relapse mortality was observed in obese individuals.
Analysis involved assessment of outcomes following a high dose cyclophosphamide conditioning regimen.
These findings indicate the need for tailored conditioning strategies in overweight and obese transplant recipients.