Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT

Alycia Hatashima; Xinyi Fan; Jeanne McCarthy-Kaiser; Amanda Peffer; Chris Davis; Ryan Basom; Bee Chua; Natalie Wuliji; Masumi Ueda; Prof. Brenda M. Sandmaier; Timothy W Randolph; Marco Mielcarek; Naveed J. Ali

doi:10.1016/j.jtct.2025.12.108

February 1, 2026Transplantation and Cellular Therapy

Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT

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Key Points

Severe acute GVHD and non-relapse mortality rates are significantly higher in overweight and obese patients.
A notable 30% increase in non-relapse mortality was observed in obese individuals.
Analysis involved assessment of outcomes following a high dose cyclophosphamide conditioning regimen.
These findings indicate the need for tailored conditioning strategies in overweight and obese transplant recipients.

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Observational analysis finds higher rates of severe acute GVHD and non-relapse mortality in overweight and obese patients undergoing allogeneic hematopoietic cell transplantation, suggesting...

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Hatashima et al. (2026) studied this question.

synapsesocial.com/papers/69a76068c6e9836116a2d1f7 https://doi.org/10.1016/j.jtct.2025.12.108

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Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT

Key Points

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Implication

Discussion

Cite This Study

Higher Incidence of Severe Acute GVHD and NRM Following High Dose Cyclophosphamide Based Conditioning Regimen in Overweight and Obese Patients Undergoing Allogeneic HCT

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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