Brief pulses of high-level fluid shear stress enhance metastatic potential and rapidly alter the metabolism of cancer cells

Key Points

• Metastatic potential is enhanced by brief pulses of fluid shear stress, indicating aggressive behavior in cancer cells.
• Significant metabolic changes occur rapidly within cancer cells when exposed to high-level fluid shear stress.
• Assessment using fluid mechanical techniques demonstrated notable alterations in cancer cell physiology under stress conditions.
• Results highlight the need for further investigation into the role of mechanical forces in tumor biology and treatment responses.