March 3, 2026Open Access

Persistently high prevalence of HPV16 and rising prevalence of non-16/18 HR-HPV genotypes in cervical precancer and cancer in Latvia in 2016-2024 shape the severity of cervical disease

Key Points

Cervical disease severity correlates with specific hr-hpv loads and the number of hr-hpvs present, indicating a complex viral interaction.
Hpv16 remains the most prevalent hr-hpv while other hr-hpv genotypes such as hpv66/45/39/31/33 are increasing in frequency.
Assessment of viral load and genotyping is essential for understanding the worsening severity of cervical disease.
Further epidemiological studies are necessary to analyze historical and contemporary samples for better insights.

Abstract

HPV16 remained the most prevalent HR-HPV, while HPV18 decreased. Other HR-HPV genotypes (HPV 66/45/39/31/33) demonstrated an increase in prevalence. Cervical disease severity was linked to specific HR-HPV loads and the number infecting HR-HPVs. These findings highlight the need for extended HR-HPV genotyping with determination of viral load, and request more epidemiological studies analyzing historical and current samples.

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Discussion

Journals

SHILAP Revista de lepidopterología

Frontiers in Oncology

Institutions

Karolinska Institutet

Riga Stradiņš University

Central Research Laboratories (United Kingdom)

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