Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults

Key Points

• This research aims to evaluate the differences in weight loss effects of GLP-1 receptor agonists across various subpopulations, particularly men and women.
• Conducted a systematic review and meta-analysis of studies on GLP-1 receptor agonists.
• Analyzed treatment effects in different demographic groups, focusing on gender.
• Assessed overall efficacy in various subpopulations.
• GLP-1 receptor agonists led to greater weight loss in women compared to men.
• Efficacy was consistent across other key demographic groups.
• Findings provide insights for personalized treatment strategies.