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March 4, 2026JAMA Internal Medicine18 citations

Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults

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GAG. Caleb AlexanderXXXuya XiaoSDSophie Dilek

Key Points

  • This research aims to evaluate the differences in weight loss effects of GLP-1 receptor agonists across various subpopulations, particularly men and women.
  • Conducted a systematic review and meta-analysis of studies on GLP-1 receptor agonists.
  • Analyzed treatment effects in different demographic groups, focusing on gender.
  • Assessed overall efficacy in various subpopulations.
  • GLP-1 receptor agonists led to greater weight loss in women compared to men.
  • Efficacy was consistent across other key demographic groups.
  • Findings provide insights for personalized treatment strategies.

Abstract

In this systematic review and meta-analysis, GLP-1 RAs produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations. These findings may inform clinical decision-making.

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Cite This Study

Alexander et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd4fd48f933b5eed993dhttps://doi.org/10.1001/jamainternmed.2025.8222
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