This study provides a comprehensive longitudinal analysis of hippocampal subfield atrophy, inter-regional co-atrophy patterns, and network centrality during MCI-to-AD progression. Our findings demonstrate that several subfields, including the left CA1 and dentate gyrus, are structurally and functionally central in the hippocampal atrophy network. The integration of volumetric, correlation-based, and graph theory-based approaches offers new insights into the coordinated degeneration of the hippocampus in AD, emphasizing the importance of subfield-level network dynamics in understanding the disease progression.
Lim et al. (Sun,) studied this question.