Longitudinal analysis finds subfield atrophy linked to cognitive decline in Alzheimer's disease, indicating network dynamics are crucial for understanding progression.
This study provides a comprehensive longitudinal analysis of hippocampal subfield atrophy, inter-regional co-atrophy patterns, and network centrality during MCI-to-AD progression. Our findings demonstrate that several subfields, including the left CA1 and dentate gyrus, are structurally and functionally central in the hippocampal atrophy network. The integration of volumetric, correlation-based, and graph theory-based approaches offers new insights into the coordinated degeneration of the hippocampus in AD, emphasizing the importance of subfield-level network dynamics in understanding the disease progression.
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Lim et al. (2026) studied this question.
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