TyG index, TG/HDL-C, and METS-IR were independently associated with SLVD in type 2 diabetes patients, with predictive AUCs of 0.785, 0.798, and 0.819 respectively, showing no significant difference among them.
Observational (n=221)
Examiner blinded to clinical information
No
Do non-insulin-based insulin resistance indices (TyG index, TG/HDL-C, and METS-IR) predict subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus?
Non-insulin-based insulin resistance indices (TyG, TG/HDL-C, and METS-IR) are effective and comparable surrogate markers for identifying subclinical left ventricular dysfunction in patients with type 2 diabetes.
Effect estimate: TyG index OR 4.27 (95% CI 2.62-6.95), TG/HDL-C OR 1.22 (1.13-1.32), METS-IR OR 1.28 (1.19-1.38) for prediction of SLVD
p-value: p=<0.001 for all
Current research indicates that novel non-insulin-based insulin resistance indicators—including the triglyceride-glucose (TyG) index, triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), and Metabolic Score for Insulin Resistance (METS-IR)—are closely associated with cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). Notably, the TyG index demonstrates significant correlation with subclinical left ventricular dysfunction (SLVD), making it a potential biomarker for early detection of SLVD in T2DM patients. However, the predictive value of TG/HDL-C and METS-IR in this context remains unclear, and no comparative analysis of their predictive efficacy has been conducted. The objective of this study is to evaluate and compare the predictive value of these three indices for SLVD in T2DM patients. A total of 221 hospitalized patients with T2DM from the Department of Endocrinology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), between June 2024 and February 2025, were included. Participants were categorized into SLVD (left ventricular global longitudinal strain, GLS 0.05). TyG index, TG/HDL-C, and METS-IR are significantly associated with SLVD in T2DM patients and demonstrate good predictive performance. These indices are valuable for clinical application, especially in primary care settings, though no significant difference in predictive efficacy was observed among them.
Zhong et al. (Sat,) conducted a observational in Hospitalized adult patients (≥18 years) with type 2 diabetes mellitus, preserved LV ejection fraction (≥50%), without significant cardiac valve disease, coronary artery disease, or arrhythmia (n=221). Insulin resistance indices (TyG index, TG/HDL-C ratio, METS-IR) vs. Non-SLVD group (GLS ≥18%) was evaluated on Subclinical left ventricular dysfunction (SLVD) defined as global longitudinal strain (GLS) <18% assessed by speckle-tracking echocardiography (TyG index OR 4.27 (95% CI 2.62-6.95), TG/HDL-C OR 1.22 (1.13-1.32), METS-IR OR 1.28 (1.19-1.38) for prediction of SLVD, p=<0.001 for all). TyG index, TG/HDL-C, and METS-IR were independently associated with SLVD in type 2 diabetes patients, with predictive AUCs of 0.785, 0.798, and 0.819 respectively, showing no significant difference among them.