What question did this study set out to answer?

The aim is to develop a method for synthesizing noncanonical α, β-diamino acids using cross-dehydrogenative coupling.

March 10, 2026Open Access

EDA Complex–Mediated C(sp 3 )–H Cross‐Dehydrogenative Coupling Enables Synthesis of Noncanonical α , β ‐Diamino Acids

Key Points

The aim is to develop a method for synthesizing noncanonical α, β-diamino acids using cross-dehydrogenative coupling.
Employed photoinduced cross-dehydrogenative coupling (CDC)
Utilized N-arylglycine derivatives and amides
Achieved regioselective C(sp 3)–C(sp 3) cross-coupling
Successfully synthesized noncanonical α, β-diamino acids from simple precursors
Demonstrated effective coupling via electron donor–acceptor complex
Provided a new approach to access bioactive compounds

Abstract

Nonproteinogenic α , β ‐diamino acids are key motifs in bioactive compounds. We report a photoinduced cross‐dehydrogenative coupling (CDC) of N ‐arylglycine derivatives with amides. This reaction proceeds via an electron donor–acceptor (EDA) complex that enables regioselective C(sp 3 )–C(sp 3 ) cross‐coupling, providing access to non‐canonical α , β ‐diamino acids from simple precursors.

EDA Complex–Mediated C(sp 3 )–H Cross‐Dehydrogenative Coupling Enables Synthesis of Noncanonical α , β ‐Diamino Acids

Key Points

Abstract

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