Photoinduced cross-dehydrogenative coupling synthesizes noncanonical α,β-diamino acids, suggesting new pathways in medicinal chemistry.
Nonproteinogenic α , β ‐diamino acids are key motifs in bioactive compounds. We report a photoinduced cross‐dehydrogenative coupling (CDC) of N ‐arylglycine derivatives with amides. This reaction proceeds via an electron donor–acceptor (EDA) complex that enables regioselective C(sp 3 )–C(sp 3 ) cross‐coupling, providing access to non‐canonical α , β ‐diamino acids from simple precursors.
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Sachidanandan et al. (2026) studied this question.
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