February 11, 2020Open Access

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

AMAjit MagadumUniversity of South Florida NSNeha SinghQuantify Research (Sweden)AKAnn KurianUniversity of North Carolina at Chapel Hill

Structured PICO

Population

Cardiomyocytes (preclinical model)

Intervention

Cardiomyocyte-specific Pkm2 modified RNA gene delivery

Outcome

Cardiomyocyte cell cycle regulation, oxidative stress, and cardiac regeneration

Pkm2 modified RNA shows therapeutic potential as a gene delivery platform to promote cardiac regeneration by regulating the cardiomyocyte cell cycle.

Abstract

We demonstrate that Pkm2 is an important intrinsic regulator of the cardiomyocyte cell cycle and oxidative stress, and highlight its therapeutic potential using cardiomyocyte-specific Pkm2 modified RNA as a gene delivery platform.

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Cite This Study

Magadum et al. (Tue,) studied this question.

synapsesocial.com/papers/69b4f8767dc62df1abb3f552 https://doi.org/https://doi.org/10.1161/circulationaha.119.043067

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