Pkm2 modified RNA shows therapeutic potential as a gene delivery platform to promote cardiac regeneration by regulating the cardiomyocyte cell cycle.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for Pkm2-based regeneration; leaves open translation from rodent models to clinical heart failure.
We demonstrate that Pkm2 is an important intrinsic regulator of the cardiomyocyte cell cycle and oxidative stress, and highlight its therapeutic potential using cardiomyocyte-specific Pkm2 modified RNA as a gene delivery platform.
No takes yet. Share an insight, caveat, or question.
Magadum et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: