CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner
Key Points
This research aims to investigate the role of the METTL3/IGF2BP1-CKS2 axis in osteosarcoma progression.
Identified the METTL3/IGF2BP1-CKS2 axis
Assessed m6A-dependent mRNA stabilization
Evaluated the contribution of CKS2 to osteosarcoma progression.
Revealed a significant role for CKS2 in osteosarcoma progression
Highlighted a regulatory mechanism involving METTL3 and IGF2BP1
Suggested CKS2 as a potential therapeutic target for treatment.
Abstract
Our study identified a METTL3/IGF2BP1-CKS2 axis that promotes OS progression via m6A-dependent mRNA stabilization, highlighting CKS2 as a potential therapeutic target.