CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Zhiyong Feng; Li Zhang

doi:10.1080/08830185.2026.2641449

March 13, 2026International Reviews of Immunology

CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

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Key Points

This research aims to investigate the role of the METTL3/IGF2BP1-CKS2 axis in osteosarcoma progression.
Identified the METTL3/IGF2BP1-CKS2 axis
Assessed m6A-dependent mRNA stabilization
Evaluated the contribution of CKS2 to osteosarcoma progression.
Revealed a significant role for CKS2 in osteosarcoma progression
Highlighted a regulatory mechanism involving METTL3 and IGF2BP1
Suggested CKS2 as a potential therapeutic target for treatment.

Implication

Study reveals CKS2 as a therapeutic target in osteosarcoma progression via METTL3 and IGF2BP1 regulation.

Abstract

Our study identified a METTL3/IGF2BP1-CKS2 axis that promotes OS progression via m⁶A-dependent mRNA stabilization, highlighting CKS2 as a potential therapeutic target.

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8d83145bc643d1c458 https://doi.org/10.1080/08830185.2026.2641449

View at Publisher

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CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Key Points

Implication

Abstract

Discussion

Cite This Study

CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner

Key Points

Implication

Abstract

Discussion

Cite This Study

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