Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing | Synapse
March 18, 2026Open Access
Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing
Key Points
This research investigates whether mupirocin decolonization affects the performance of MRSA PCR nasal swab testing.
Evaluated the negative predictive value (NPV) of MRSA PCR nasal swabs after mupirocin treatment.
Conducted testing within 7 days of initiating mupirocin decolonization.
Compared MRSA PCR results before and after decolonization.
NPV of MRSA PCR nasal swabs remains unchanged following mupirocin decolonization.
Testing within 7 days of decolonization is non-inferior to testing prior to decolonization.
Abstract
The NPV of MRSA PCR nasal swabs is not diminished after mupirocin decolonization. MRSA PCR testing within 7 days of initiation of decolonization is non-inferior to testing prior to decolonization.