Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing

Andrea S Ito; Kaitlyn Reasoner; Sharon K Ong’uti; Edward T. Qian; Zhiguo Zhao; Rebecca Stern; Jeffrey A Freiberg

doi:10.1093/cid/ciag183

March 12, 2026Clinical Infectious DiseasesOpen Access

Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing

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Key Points

This research investigates whether mupirocin decolonization affects the performance of MRSA PCR nasal swab testing.
Evaluated the negative predictive value (NPV) of MRSA PCR nasal swabs after mupirocin treatment.
Conducted testing within 7 days of initiating mupirocin decolonization.
Compared MRSA PCR results before and after decolonization.
NPV of MRSA PCR nasal swabs remains unchanged following mupirocin decolonization.
Testing within 7 days of decolonization is non-inferior to testing prior to decolonization.

Implication

Evaluation reveals that mupirocin decolonization does not affect MRSA PCR nasal swab testing efficacy.

Abstract

The NPV of MRSA PCR nasal swabs is not diminished after mupirocin decolonization. MRSA PCR testing within 7 days of initiation of decolonization is non-inferior to testing prior to decolonization.

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Cite This Study

Ito et al. (2026) studied this question.

synapsesocial.com/papers/69ba432b4e9516ffd37a4208 https://doi.org/10.1093/cid/ciag183

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Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing

Key Points

Implication

Abstract

Discussion

Cite This Study

Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing

Key Points

Implication

Abstract

Discussion

Cite This Study

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