What question did this study set out to answer?

To compare the effects of once-daily and twice-daily dosages of prednisolone on polydipsia and polyuria in dogs.

March 18, 2026

Comparison of polydipsia and polyuria in dogs treated with once‐daily or divided twice‐daily oral prednisolone in 12 dogs

EKEleni KouklakiAristotle University of Thessaloniki AKA.O. KonstantinidisAristotle University of Thessaloniki EME. MeletisUniversity of Thessaly

Key Points

To compare the effects of once-daily and twice-daily dosages of prednisolone on polydipsia and polyuria in dogs.
Observed 12 dogs under treatment for polydipsia and polyuria
Compared once-daily and divided twice-daily dosing of prednisolone
Measured urine specific gravity and osmolality for assessment of urine concentration.
Once-daily dosing of prednisolone significantly reduced excessive water intake
Urine specific gravity and osmolality showed interchangeable results in assessing urine concentration.

Abstract

Once-daily rather than divided-daily dosing is a reasonable option in dogs treated with oral prednisolone to reduce excessive water intake in the clinical setting. Urine specific gravity and osmolality can be used interchangeably for the assessment of urine concentration.

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