Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

Key Points

• This research aims to explore how age at onset affects visual acuity outcomes in people with Leber hereditary optic neuropathy (LHON).
• Analyzed visual acuity trajectories over five years
• Grouped participants by age at onset
• Assessed differences between sexes and mtDNA mutations
• Younger onset (≤19 years) linked to better visual recovery
• Older onset (≥50 years) associated with consistently worse vision
• Age at onset significantly modifies visual prognosis over five years