Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

Yasuyuki Takai; Akiko Yamagami; Mayumi Iwasa; Kenji Inoue; Ryoma Yasumoto; Hitoshi Ishikawa; Masato Wakakura

doi:10.1016/j.jcjo.2026.02.011

March 12, 2026

Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

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Key Points

This research aims to explore how age at onset affects visual acuity outcomes in people with Leber hereditary optic neuropathy (LHON).
Analyzed visual acuity trajectories over five years
Grouped participants by age at onset
Assessed differences between sexes and mtDNA mutations
Younger onset (≤19 years) linked to better visual recovery
Older onset (≥50 years) associated with consistently worse vision
Age at onset significantly modifies visual prognosis over five years

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Implication

Longitudinal analysis shows visual recovery varies with age at onset in individuals with LHON, indicating important prognostic factors.

Abstract

In this cohort, onset at ≤19 years was associated with earlier and greater visual recovery, whereas onset at ≥50 years was associated with persistently worse vision. Age at onset is an important modifier of 5-year visual prognosis in bilaterally affected LHON.

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Cite This Study

Takai et al. (2026) studied this question.

synapsesocial.com/papers/69ba44154e9516ffd37a5e8b https://doi.org/10.1016/j.jcjo.2026.02.011

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Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Five-year post-onset visual acuity trajectories in Japanese Leber hereditary optic neuropathy: a longitudinal analysis by age, sex, and mtDNA mutation.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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