What question did this study set out to answer?

The aim is to compare the efficacy of various intralesional therapies for keloid scars.

March 22, 2026Open Access

Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis

Key Points

The aim is to compare the efficacy of various intralesional therapies for keloid scars.
Conducted a network meta-analysis of available intralesional therapies.
Evaluated combination therapies including 5-FU, corticosteroids, and YAG laser.
Considered novel agents like insulin and BTX-A in the evaluation.
Combination therapies, especially 5-FU + corticosteroids + YAG laser, showed the highest effectiveness.
Novel agents demonstrated some potential, but further research is necessary.
Standardized methodologies and longer follow-up are essential for optimal treatment guidelines.

Abstract

This NMA provides a comparative overview, indicating that combination therapies, most notably 5-FU + corticoids + YAG:Laser, offer the greatest benefit. While data for novel agents (insulin and BTX-A) suggest potential, further research with standardized methodologies and longer-term follow-up is crucial to define optimal treatment algorithms.

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Cite This Study

Cruz et al. (Fri,) studied this question.

synapsesocial.com/papers/69bf8692f665edcd009e8f54 https://doi.org/https://doi.org/10.1080/07853890.2026.2619295

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