What question did this study set out to answer?

To investigate the effect of melatonin on small intestine damage caused by radiotherapy in rats.

March 25, 2026

Administration of melatonin in small intestine damage induced by flattening filter and flattening filter free radiotherapy in rat: a histopathological and biochemical study

Key Points

To investigate the effect of melatonin on small intestine damage caused by radiotherapy in rats.
Administered melatonin to rats undergoing radiotherapy
Evaluated histopathological changes in small intestine
Assessed biochemical markers of oxidative stress and apoptosis
Melatonin significantly reduced oxidative stress in small intestine
Decreased apoptosis rates were observed histopathologically
Preserved integrity of small intestinal tissue was noted after melatonin administration

Abstract

Melatonin significantly reduced radiotherapy-induced oxidative stress and apoptosis in healthy small intestinal tissue histopathologically and biochemically. These findings suggest that melatonin may act as an effective radioprotective agent by preserving small intestinal integrity during abdominopelvic radiotherapy.

اسأل الذكاء الاصطناعي

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