Histopathological and biochemical analyses show melatonin reduces oxidative stress in small intestine during radiotherapy, suggesting protective benefits.
Melatonin significantly reduced radiotherapy-induced oxidative stress and apoptosis in healthy small intestinal tissue histopathologically and biochemically. These findings suggest that melatonin may act as an effective radioprotective agent by preserving small intestinal integrity during abdominopelvic radiotherapy.
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Erdem et al. (2026) studied this question.
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