Chemical Emulation of the Biosynthesis of (±)-Arnebidin

Key Points

• The central aim is to achieve a total synthesis of (±)-arnebidin using a biomimetic approach.
• Conducted a 13-step synthesis process
• Utilized intermolecular Diels-Alder homodimerization
• Facilitated spontaneous dehydrogenation and intramolecular cycloaddition
• Synthesis performed under ambient conditions
• Produced a single diastereomer of (±)-arnebidin
• Achieved synthesis from 1,5-dihydroxynaphthalene
• Demonstrated efficiency of the synthetic route