Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era

Key Points

• The research compares the effectiveness of slow-release oral morphine and methadone for treating opioid use disorder in adults.
• Comparative effectiveness study design
• Population: Adults with opioid use disorder
• Comparison of slow-release oral morphine and methadone
• Assessment of treatment discontinuation and adherence rates
• Slow-release oral morphine was linked to a higher risk of treatment discontinuation compared to methadone.
• Adherence rates were lower for slow-release oral morphine than for methadone.
• Both medications demonstrated similar mortality risk.