Exploring the biological mechanism of Wendan decoction against COPD based on UHPLC-DAD: experimental validation and molecular docking

Key Points

• This research aims to clarify how Wendan decoction helps treat COPD by examining its effect on inflammation pathways.
• Utilized UHPLC-DAD for compound analysis of Wendan decoction.
• Conducted experimental tests to observe its effects on COPD models.
• Performed molecular docking studies to explore interactions with cellular targets.
• Wendan decoction significantly reduced pulmonary inflammation in COPD models.
• Inhibition of the NF-κB-NLRP3 signaling pathway was observed.
• Molecular docking suggested strong binding between decoction compounds and inflammatory targets.