Exploring the biological mechanism of Wendan decoction against COPD based on UHPLC-DAD: experimental validation and molecular docking

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Key Points

This research aims to clarify how Wendan decoction helps treat COPD by examining its effect on inflammation pathways.
Utilized UHPLC-DAD for compound analysis of Wendan decoction.
Conducted experimental tests to observe its effects on COPD models.
Performed molecular docking studies to explore interactions with cellular targets.
Wendan decoction significantly reduced pulmonary inflammation in COPD models.
Inhibition of the NF-κB-NLRP3 signaling pathway was observed.
Molecular docking suggested strong binding between decoction compounds and inflammatory targets.

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Experimental validation reveals that Wendan decoction alleviates COPD by inhibiting inflammation, suggesting a therapeutic potential.

Wendan decoction alleviates COPD by inhibiting pulmonary inflammation via the NF-κB-NLRP3/AA signaling pathway.

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Yu et al. (2026) studied this question.

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