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April 13, 2024Combinatorial Chemistry & High Throughput ScreeningOpen Access

Network Pharmacology and Experimental Validation of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-155-5p

Jianjun Wu Pingan Zhang Mingzhe Chen Wei-Sha Du Yi Zhang Yang Jiao Xin Li

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Abstract

Jinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of human histone deacetylase-2 (HDAC2). However the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear.

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Wu et al. (2024) studied this question.

synapsesocial.com/papers/68e6f4bdb6db64358766f610 https://doi.org/10.2174/0113862073279344240215050056

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