Right-left cusp fusion in bicuspid aortic valves independently increased the risk of more than mild paravalvular leak after TAVI (OR 7.7) compared to other valve subtypes.
Cohort (n=145)
No
Do specific bicuspid aortic valve subtypes and aortic root morphologies predict the occurrence of more than mild paravalvular leak in patients undergoing TAVI?
In patients with bicuspid aortic valve stenosis undergoing TAVI, right-left cusp fusion, larger sinotubular junction dimensions, pre-existing atrial fibrillation, and the use of self-expanding prostheses independently predict a higher risk of more than mild paravalvular leak.
Effect estimate: OR 7.7 (95% CI 1.34-44.4)
Absolute Event Rate: 33.6% vs 9.7%
p-value: p=0.02
The incidence of more than mild PVL varied with BAV subtypes and aortic root morphology. Independent factors increasing PVL risk included R-L cusp fusion, self-expanding prosthesis use, extended STJ short axis, and pre-existing atrial fibrillation.
Nieznańska et al. (Wed,) conducted a cohort in Bicuspid aortic valve stenosis (n=145). Transcatheter aortic valve implantation (TAVI) vs. Other bicuspid aortic valve subtypes was evaluated on Occurrence of more than mild paravalvular leak (PVL) (OR 7.7, 95% CI 1.34-44.4, p=0.02). Right-left cusp fusion in bicuspid aortic valves independently increased the risk of more than mild paravalvular leak after TAVI (OR 7.7) compared to other valve subtypes.