What question did this study set out to answer?

To investigate the differences in neutrophil phenotype and function in older adults experiencing frailty compared to those aging in good health.

April 1, 2026Open Access

Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Key Points

To investigate the differences in neutrophil phenotype and function in older adults experiencing frailty compared to those aging in good health.
Analyzed neutrophil signaling pathways in older adults with frailty and good health.
Assessed chemotaxis ability, reactive oxygen species (ROS) production, and NET (neutrophil extracellular trap) formation.
Compared findings to chronic inflammation observed in rheumatoid arthritis (RA).
Older individuals with frailty demonstrate impaired chemotaxis compared to their healthier counterparts.
Increased production of reactive oxygen species (ROS) was noted in neutrophils from frail individuals.
Alterations in neutrophil phenotype showed similarities to chronic inflammation patterns seen in RA.

Abstract

This work provides novel insight into the altered neutrophil phenotype associated with ageing in good health and ageing with frailty, and highlights similarities between inflammageing in frailty and chronic inflammation in RA. This may be important in the development of therapeutics and/or health management strategies to support healthy living as we age.

Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Key Points

Abstract

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