Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Genna Ali Abdullah; John Walsh; Andrew Sellin; Cody McLean; Asangaedem Akpan; M Phelan; H. J. Wright

doi:10.1093/cei/uxag019

March 27, 2026Clinical & Experimental ImmunologyOpen Access

Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

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Key Points

To investigate the differences in neutrophil phenotype and function in older adults experiencing frailty compared to those aging in good health.
Analyzed neutrophil signaling pathways in older adults with frailty and good health.
Assessed chemotaxis ability, reactive oxygen species (ROS) production, and NET (neutrophil extracellular trap) formation.
Compared findings to chronic inflammation observed in rheumatoid arthritis (RA).
Older individuals with frailty demonstrate impaired chemotaxis compared to their healthier counterparts.
Increased production of reactive oxygen species (ROS) was noted in neutrophils from frail individuals.
Alterations in neutrophil phenotype showed similarities to chronic inflammation patterns seen in RA.

Implication

This work uncovers altered neutrophil functions in aging and frailty, suggesting implications for health management.

Abstract

This work provides novel insight into the altered neutrophil phenotype associated with ageing in good health and ageing with frailty, and highlights similarities between inflammageing in frailty and chronic inflammation in RA. This may be important in the development of therapeutics and/or health management strategies to support healthy living as we age.

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Cite This Study

Abdullah et al. (2026) studied this question.

synapsesocial.com/papers/69ccb7b016edfba7beb89b18 https://doi.org/10.1093/cei/uxag019

View Full Paper

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Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Key Points

Implication

Abstract

Discussion

Cite This Study

Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Key Points

Implication

Abstract

Discussion

Cite This Study

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