What question did this study set out to answer?

To compare the effectiveness and safety of preoperative biliary drainage (PBD) versus upfront surgery in patients with moderate jaundice prior to pancreaticoduodenectomy.

April 3, 2026Open Access

Preoperative biliary drainage versus upfront surgery in moderately jaundiced patients undergoing pancreaticoduodenectomy: A single-institution comparative study

Key Points

To compare the effectiveness and safety of preoperative biliary drainage (PBD) versus upfront surgery in patients with moderate jaundice prior to pancreaticoduodenectomy.
Single-institution comparative study
Compared outcomes of patients with moderate jaundice undergoing PBD versus upfront surgery
Analyzed rates of surgical site infections, bile contamination, and costs.
Upfront pancreaticoduodenectomy can be safely performed in moderate jaundice patients.
Routine preoperative biliary drainage showed no clinical benefits.
PBD was associated with higher rates of surgical site infections and bile contamination.

Abstract

In patients with moderate jaundice (10-15 mg/dL), upfront PD can be performed safely. Routine PBD offers no clinical benefit and is associated with higher rates of SSIs, bile contamination, and increased costs.

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