What question did this study set out to answer?

The study aims to identify shared molecular mechanisms involved in skin and lung fibrosis in systemic sclerosis.

April 5, 2026

Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis

Key Points

The study aims to identify shared molecular mechanisms involved in skin and lung fibrosis in systemic sclerosis.
Conducted transcriptomic analysis of skin samples from systemic sclerosis patients.
Deconvoluted severe cutaneous transcriptomic signatures to identify enriched pathways.
Focused on specific cell types including stromal and immune cells.
Identified significant cutaneous transcriptomic signatures associated with multiorgan involvement.
Enriched pathways include KRAS in stromal cells and interactions between stromal and immune cells.
Provided a framework for understanding mechanisms behind skin and lung fibrosis.

Abstract

We found a severe cutaneous transcriptomic signature of SSc associated with multiorgan involvement. By deconvoluting the severe cutaneous signature, we have identified pathways enriched in specific cell types including KRAS in stromal cells, and a combination of stromal and immune cells in the severe signature. The severe SSc signature can provide a framework for understanding shared mechanisms in skin and lung fibrosis and may help identify additional molecular pathways.

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