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April 5, 2026Arthritis & Rheumatology

Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis

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Authors

JZJ. ZielonkaNLN. LiYLYing Liu

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Overview

Transcriptomic analysis reveals shared molecular pathways in skin and lung involvement, suggesting insights into systemic sclerosis.

Key Points

  • The study aims to identify shared molecular mechanisms involved in skin and lung fibrosis in systemic sclerosis.
  • Conducted transcriptomic analysis of skin samples from systemic sclerosis patients.
  • Deconvoluted severe cutaneous transcriptomic signatures to identify enriched pathways.
  • Focused on specific cell types including stromal and immune cells.
  • Identified significant cutaneous transcriptomic signatures associated with multiorgan involvement.
  • Enriched pathways include KRAS in stromal cells and interactions between stromal and immune cells.
  • Provided a framework for understanding mechanisms behind skin and lung fibrosis.

Cite This Study

Zielonka et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd62a79560c99a0a367fhttps://doi.org/10.1002/art.70163
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